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It is for patients who are using a total skin care and sunlight avoidance program. Renova is a prescription cream containing Tretinoin, a form of vitamin A. It is used to treat signs of sun damage, including fine facial wrinkles, uneven dark spots, and rough skin texture. It works by promoting skin cell renewal as part of your skincare program. But, can you get tretinoin over the counter (OTC) or does it require a prescription from a healthcare provider? In this article, we will explore the availability of tretinoin, including whether or not it can be purchased without a prescription, and where and how you can get it. Save up to 80% on your Renova prescription at pharmacies nationwide. Compare Renova prices at 60,000+ US pharmacies. Get a free Rx.com coupon and save up to 90% on your prescription. Without a patient assistance program, Renova costs more than many patients expect for a skincare prescription. What you'd pay depends on factors outside your control. 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